Due to blood-retinal barrier, drug administration is often limited for the treatment of vitreoretinal disorders. Intravitreal drug injection is an effective method as it can directly deliver drugs to act on vitreous body and retina. However, for chronic and recurrent diseases, injection needs to be repeated frequently to achieve effective drug concentration. Ocular implants, which not only avoid blood-retinal barrier but also extent action time, have become a new treatment for vitreoretinal disorders. Different implants can treat different diseases. Antiviral drug implant can be effective in the treatment of cytomegalovirus retinitis for the acquired immunodeficiency syndrome patients. Steroid implant can be effective in the treatment of chronic inflammatory fundus diseases such as macular edema and noninfectious uveitis. The main side effects were elevated intraocular pressure and cataract formation. Ciliary neurotrophic factor and anti-vascular endothelial growth factor implants may be the effective drugs for the treatment of age-related macular degeneration. This article reviewed the clinical applications of current major intravitreal implants on vitreoretinal disorders.

国家自然科学基金(面上项目)(No.81271019)