氧化应激及补体在年龄相关性黄斑变性发病中的作用机制

Mechanism of oxidative stress and complement in the pathogenesis of age-related macular degeneration

摘要:

年龄相关性黄斑变性(AMD)是受环境和遗传因素共同影响的一种复杂疾病，目前已成为老年人最普遍的致盲原因之一。其发病机制与长期的慢性氧化应激及免疫炎症反应对组织的损伤密切相关。以下将氧化应激、补体及局部炎症在AMD发病中的作用机制作简要综述。

Abstract:

Age-related macular degeneration(AMD), one of the most common causes of elderly blindness, is a complex disease results from environmental and genetic factors. AMD pathogenesis is associated with chronic oxidative stress, immune and inflammatory damage. We make a simple generalization of oxidative stress and complement in the pathogenesis of AMD in this article.