[关键词]
[摘要]
目的：利用频域三维相干光学断层扫描(three dimensional frequency domain coherent optical tomography，3D-OCT)评估准分子激光原位角膜磨镶术(laser
in situ keratomileusis，LASIK)对视网膜神经纤维层厚度(retinal nerve fibre layer thickness，RNFLT)的影响。
方法：对83例83右眼接受LASIK治疗的受试者分别于术前及术后1d； 1wk； 1，3mo行3D-OCT检查，测量视乳头上方、下方、鼻侧、颞侧及12个钟点位RNFLT，利用重复测量方差分析及配对t检验对术前及术后的数据统计学处理。
结果：术前及术后各时间点行重复测量方差分析显示，视乳头下方、颞侧、5：00～11：00位RNFLT均值无显著差异(P>0.05)，而视乳头上方、鼻侧、1：00～4：00位、12：00位RNFLT有显著差异(P<0.05)； 进一步对术前及术后各时间点视乳头上方、鼻侧、1：00～4：00位、12：00位RNFLT分别行配对t检验得出，术后1d时视乳头上方、鼻侧及1：00～4：00位、12：00位RNFLT较术前变薄，差异有统计学意义(P<0.05)，术后1wk； 1，3mo时以上各方位RNFLT较术前比较均无统计学差异(P>0.05)。同时表明RNFLT变薄与屈光度及激光时间成正相关。
结论：LASIK术后早期上方及鼻侧RNFLT变薄，但术后1wk恢复至正常水平，LASIK手术对RNFLT无长远影响。
[Key word]
[Abstract]
AIM: To evaluate the change of retinal nerve fiber layer thickness(RNFLT)after laser
in situ keratomileusis(LASIK)by three dimensional frequency domain optical coherent tomography(3D-OCT).
METHODS:Eighty-three patients(83 right eyes)who underwent LASIK operation were recruited. RNFLT was performed by 3D-OCT preoperatively and 1 day, 1 week, 1 month and 3 months postoperatively. The data was analyzed with repeated measures ANOVA and paired t test.
RESULTS: After the comparisons of the RNFL thickness among different time points, we found no statistical differences excluding the RNFLT of superior, nasal and 12, 1-4 o'clock sectors through the repeated measures with ANOVA.Then using paired t test for further analysis, the difference was not remained in the follow-up observation. There was also a significant correlation between RNFLT and diopter(superior r=-0.316, P=0.004; nasal r=-0.456, P<0.001)and laser cutting time(superior r=0.341, P=0.002; nasal r=0.471, P<0.001), but no significant correlation between RNFLT and age and suction time.
CONCLUSION: There is no change of RNFLT after LASIK during the follow-up.
[中图分类号]
[基金项目]
2011年宁夏自治区卫生厅医疗卫生科研计划项目(No.2011039)
