模拟失重状态下VEP及OPs与远近视力相关性的分析

Analysis of relationship among visual evoked potential, oscillatory potential and visual acuity under stimulated weightlessness

摘要:

目的：分析在模拟失重状态下，反映视功能的视觉诱发电位(VEP)及反映视网膜供血的振荡电位(OPs)与远近视力的相关性。

方法：选取14例男性健康志愿者，-6°头低位模拟失重状态，在受试前、受试第2d及受试第5d记录远近视力、VEP及OPs。VEP标记P₁₀₀波，OPs按照国际视觉电生理协会的临床电生理标准(2008年修订)记录总和波。结果进行统计学分析。

结果：P₁₀₀波幅及OPs总和波在受试后发生显著的变化(P=0.0152，P=0.0238)。将这两项结果与远近视力进行相关性分析，未见明显相关。

结论：头低位模拟失重状态导致全身血液重新分布，引起眼部血供的改变，这种供血的改变可以导致视觉电生理的变化，但对远近视力这种基础的视功能影响不大。

Abstract:

AIM: To observe the influence of head-down tilt simulated weightlessness on visual evoked potential(VEP), oscillatory potentials(OPs)and visual acuity, and analyse the relationship among them.

METHODS: Head-down tilt for -6° was adopted in 14 healthy volunteers. Distant visual acuity, near visual acuity, VEP and OPs were recorded before, two days and five days after trial. The record procedure of OPs followed the ISCEV standard for full-field clinical electroretinography(2008 update).

RESULTS: Significant differences were detected in the amplitude of P₁₀₀ waves and ∑OPs among various time points(P<0.05). But no relationship was observed among VEP, OPs and visual acuity.

CONCLUSION: Head-down tilt simulated weightlessness induce the rearrange of blood of the whole body including eyes, which can make the change of visual electrophysiology but not visual acuity.