方法：干眼症患者51例102眼，双眼自身对照，随机分为治疗组和对照组。治疗组给予聚乙二醇滴眼液和重组牛碱性成纤维细胞生长因子滴眼液，均4次/d，两种滴眼液之间间隔5～10min。对照组给予聚乙二醇滴眼液滴眼，4次/d，连续用药1mo后复查。观察每组用药前后Schirmer Ⅰ试验，BUT，角膜荧光素染色和症状改善情况。

结果：两组治疗前后BUT，角膜荧光素染色和症状都有显著差异(P<0.05)。两组治疗前后Schirmer Ⅰ试验结果无显著差异(P>0.05)。治疗后两组BUT，角膜荧光素染色和症状也有显著差异(P<0.05)。

结论：聚乙二醇滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液对治疗干眼症有明显的疗效。

METHODS: Fifty-one patients(102 eyes)with dry eye were divided into treating group and control group randomly. Both eyes of one were compared by each other. The eyes of treating group were treated by polyethylene glycol eye drops combined with bFGF eye drops 4 times each day for 1 month. The 2 drops were dropped 5 to 10 minutes apart each time. The eyes of control group were treated by polyethylene glycol eye drops 4 times each day for 1month. Schirmer Ⅰ test, break-up time(BUT), corneal fluorescein staining and improvement of symptoms were observed before treatment and after treatment in the two groups.

RESULTS: There was significant difference intear film break-up time(BUT), corneal fluorescein staining and symptoms between before and after the treatment of both groups(P<0.05). There was also significant difference in BUT, corneal fluorescein staining and symptoms between the two groups after the treatment(P<0.05). There was no significant difference in Schirmer Ⅰ test between all time-point of the two groups(P>0.05).

CONCLUSION: Polyethylene glycol eye drops combined with bFGF has obviously effect on dry eye.