方法：研究对象为2011-04/2012-04在本院门诊就诊的屈光不正且具有典型的视疲劳症状患者200例400眼，年龄6～18岁，入选者采用(德国施图伦大药厂)七叶洋地黄双苷滴眼液3次/d，每次1滴，共使用1mo。 通过进行调查问卷评分测定视疲劳主觉症状改善情况，以及视力和屈光度的改变和药物的不良反应。

结果：用药前后患者的视疲劳主觉症状评分：治疗前3.67，治疗结束后1.89，治疗前和治疗后差异有统计学意义(P<0.05)。患者的裸眼视力有所提高，治疗前200例400眼平均视力为4.43±0.38，治疗后为4.60±0.49，组间比较差异有统计学意义(t=-3.87，P<0.05)。治疗前后屈光度由-2.54±3.00D降至-2.25±2.98D，但差异没有统计学意义(t=-0.96，P=0.33)。没有发现明显的不良反应。

结论：七叶洋地黄滴眼液对青少年屈光不正性视疲劳安全、有效。

METHODS: Objects of study were patients with refractive asthenopia during April 2011 to April 2012, age from 6 to 18, totally 200 patients 400 eyes with typical visual fatigue symptoms were included. The enrolled patients used esculin and digitalisglycosides eye drops made by Germany, 1 drop per time,t.i.d. duration of the treatment lasted for 1 month. The improvement of treatment including visual fatigue, vision, dioptric change and drug adverse reactions were determined by conducting questionnaires rating.

RESULTS: Visual fatigue grade increased from 3.67 to 1.89 after the treatment, which had statistical significance(P<0.05). The naked eyesight of the patients improved from 4.43±0.38 to 4.60±0.49. Comparison differences between groups had statistical significance(t=-3.87, P<0.05). Dioptry decreased from -2.54±3.00D to -2.25±2.98D, but the differences had no statistical significance. There's no report for adverse reactions.

CONCLUSION:Esculin and digitalisglycosides eye drops is safe and effective in treating adolescent refractive asthenopia.