方法：前瞻性临床对照研究。药物组前房内注入头孢呋辛钠，对照组是前房内注入灌注液。入选患者分为4组：<60岁药物组，<60岁对照组，≥60岁药物组和≥60岁对照组。分别于术前，术后1，6mo光学相干断层扫描测量黄斑厚度。

结果：术后1mo，≥60岁药物组在中心凹、内下区、颞内区和外下区区域的厚度大于其他三组。术后6mo，只有≥60岁药物组的内下区的厚度大于其他三组。术后1mo，与各自术前的黄斑厚度相比，≥60岁药物组在中心凹、内下区、颞内区和外下区区域的增加的厚度大于其他三组。术后6mo，≥60岁药物组的中心凹和内下区的增加的厚度大于其他三组。

结论：白内障术后黄斑厚度增加在术后6mo尚不能恢复到术前状态。相对于较年轻患者，超过60岁的白内障患者在术中使用头孢呋辛钠会在术后1mo黄斑厚度增加更多。

METHODS: Prospective, controlled and parallel compared clinical study. Enrolled patients were divided into 4 groups based on age under or over 60 years old(<60 group and ≥60 group)and with intracameral cefuroxime(experiment group)before ending operation or with irrigating solution(control group). Macular thicknesses were measured at baseline and 1 month and 6 months postoperatively.

RESULTS: At 1 month, ≥60 experiment group has thicker fovea, inferior inner area and temporal inner area than other 3 groups. At 6 months, only inferior inner area was thicker in ≥60 experiment groups than other 3 groups. With response to preoperative value, at 1 month, 4 sectors of macular thickness were thicker in ≥60 experiment group than other 3 groups, which were forvea, inferior inner area, temporal inner area and inferior outer area. At 6 months, only 2 areas were thicker in ≥60 experiment group than other 3 groups, which were fovea and inferior inner area.

CONCLUSION: Macula becomes thicker after cataract surgery which cannot restore preoperative level at 6 months. Patients elder than 60 will have thicker macula after cataract surgery with intracameral cefuroxime at 1 month postoperatively.