[关键词]
[摘要]
目的：观察低剂量光动力学疗法(photodynamic therapy， PDT)治疗中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy， CSC)的短期疗效。
方法：选取急性CSC患者36例36眼，进行单次1/2量维替泊芬(3mg/m2)进行PDT治疗，分别于术前和术后1，4，12，24wk进行最佳矫正视力和OCT的检查，术前、术后4，24wk进行FFA和ICG检查。
结果：术后1wk，36眼中有27眼(75%)OCT显示视网膜下积液完全吸收，其余9眼(25%)视网膜下液部分吸收； 术后4wk，36眼视网膜下积液全部吸收，FFA+ICG示36眼荧光渗漏完全消失，脉络膜血管高渗透性消失； 术后12～24wk，36眼无复发。治疗后4wk，最佳矫正视力从术前平均0.52提高至0.80。随访期间36眼未见任何不良反应。
结论：低剂量PDT治疗CSC短期内安全有效，能缩短病程，显著提高视力。
[Key word]
[Abstract]
AIM:To evaluate the efficacy of photodynamic therapy(PDT)after 1/2 dose verteporfin injection in treating central serous chorioretinopathy(CSC).
METHODS:Thirty-six eyes of 36 patients diagnosed with CSC received one single session of PDT using 1/2 dose(3mg/m2)verteporfin. Best-corrected visual acuity(BCVA)and OCT were measured before, 1 week, 4, 12 and 24 weeks after PDT treatment with 1/2 dose. OCT, FFA and ICG examination were performed before, 4 and 24 weeks after PDT treatment with 1/2 dose.
RESULTS:Twenty-seven of 36 eyes(75%)had complete resolution of subretinal fluid(SRF)1 week after 1/2 dose PDT treatment. SRF was partly absorbed in 9 of 36 eyes(25%). After 4 weeks, SRF in 36 eyes was completely absorbed, fluorescein leakage of 36 eyes disappeared in FFA and the tortuous choroidal vessels appeared normal in ICG; Twelve to twenty-four weeks after PDT treatment, there was no recurrence of CSC in 36 eyes. The mean BCVA was improved from 0.52 to 0.80 four weeks after PDT treatment.
CONCLUSION:PDT with 1/2 dose verteporfin injection is effective and safe in treating CSC in short time follow-up. It can shorten the coursing of CSC and protect the macular visual function.
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