翼状胬肉切除联合角膜缘干细胞移植术前术后的泪膜变化

Influence of pterygium excision combined with autologous limbus epithelial transplantation on the function of tear film

摘要:

目的：探讨翼状胬肉切除联合角膜缘干细胞移植手术前、术后泪膜功能的变化。

方法：对24例24眼翼状胬肉患者行逆向胬肉切除联合自体角膜缘干细胞移植术，分别于术前1d； 术后1，2mo行Schirmer试验和泪膜破裂时间(BUT)检查，比较各时间点上泪膜的稳定性。

结果：患者24例术前1d； 术后1，2mo SchirmerⅠ试验分别为15.5±7.81，15.76±7.39，16.00±8.05mm，BUT分别为8.15±3.611，10.05±3.03，10.50±4.26s，术前术后BUT差异具有统计学意义(P<0.05)，Schirmer试验术后与术前比较无明显变化( P>0.05)。

结论：翼状胬肉切除联合角膜缘干细胞移植可以恢复眼表的形态及泪膜功能的稳定性。

Abstract:

AIM: To observe the changes of preoperative and postoperative tear film in the surgical treatment for pterygium by pterygium excision combined with autologous limbus epithelial transplantation, and analyse the influence of pterygium on the function of tear film.

METHODS: A total of 24 cases(24 eyes)of pterygium underwent pterygium excision combined with autologous limbus epithelial transplantation. All patients were measured by Schirmer test and tear film break-up test(BUT)on 1 day before operation, 1 month and 2 months after operation respectively.

RESULTS: The result of Schirmer test were 15.5±7.81mm, 15.76±7.39mm and 16.00±8.05mm, and BUT were 8.15±3.611, 10.05±3.03, and 10.50±4.26 seconds on 1 day before operation, 1 month and 2 months after operation respectively. The difference of BUT had statistical significance between preoperation and postoperation(P<0.05), but there was no significant change in Schirmer test in different time(P >0.05).

CONCLUSION: The form of the ocular surface and the stability of tear film were restored by pterygium excision combined with autologous limbus epithelial transplantation.