方法：对1946/2011年美国国立医学图书馆Pubmed数据库收录的相关文献采用书目信息共现挖掘系统(BICOMS)进行了文献计量分析，利用PASW 18.0统计软件对高频主题词进行了共词聚类分析并描绘了聚类关系图。

结果：共检出黄斑水肿相关文献5 871篇，发文量逐年增加。英语语种发表的文献占总文献量的83.87%。美国发文量为2 921篇(49.75%)。相关高频主题词共51个，共词聚类分析发现高频主题词聚类为7个类别，依次为糖皮质激素治疗黄斑水肿的不良反应、黄斑水肿诊断、黄斑水肿的病理/生理学、黄斑水肿的外科疗法、黄斑水肿的药物治疗、黄斑水肿治疗后所引起的不良反应、白内障摘除及超声乳化手术后黄斑水肿。

结论：国际近年对黄斑水肿的关注和发文量逐年增加，欧美国家和作者的科研发文量占主导地位。国际上黄斑水肿的研究热点主要集中在基础研究、诊断技术、手术、药物治疗几个方面。

METHODS:Macular edema related articles during 1946-2011 from PubMed database were retrieved for quantitative analysis by software of BICOMS. PASW 18.0 statistical software was used to cluster high frequency hot topics of published articles, and clustering relationship picture of high frequency hot topics were drawn.

RESULTS: Totally 5 871 macular edema related articles were retrieved, it's increasing year by year. 83.87% of the total volume of documentation of the published literature was in English. American published 2 921 macular edema related articles, which accounted for 49.75% of worldwide totally published articles. 51 high frequency hot topics were gained. High frequency hot topics were clustered into 7 categories by clustering analysis, which ranked as the adverse effects of glucocorticoid treatment of macular edema, the diagnosis of macular edema, macular edema pathology/physiology, surgical treatment of macular edema, the drug treatment of macular edema, after treatment adverse reactions, macular edema after cataract extraction and phacoemulsification.

CONCLUSION: Recently international countries pay more attention to macular edema related study, and the published macular edema related articles rapidly increased, American and European countries occupy the dominant position for the number of published macular edema related articles. The international main research focus included basic research to macular edema, the diagnosis of macular edema, surgery and drugs and treatment of macular edema.