方法：选取我院接受屈光性角膜切削术(PRK)治疗的30例57眼低、中度近视患者，术中应用0.02g/L的MMC 30s，将术后6mo的随访结果与同期接受准分子激光原位角膜磨镶术(LASIK)治疗的疗效进行比较。

结果：术后6mo，PRK+LMMC治疗组等值球镜屈光度0.210D、等值球镜屈光度在±0.50D范围内的发生率71.9%、裸眼视力≥1.0者77.2%，平均最佳矫正视力1.19±0.18； LASIK治疗组等值球镜屈光度-0.017D，等值球镜屈光度在±0.50D范围内的发生率70.1%，裸眼视力≥1.0者72.7%，平均最佳矫正视力1.16±0.19，两组比较差异均无统计学意义(P>0.05)。术后6mo，PRK+LMMC治疗组没有出现超过1级的haze，所有眼最佳矫正视力均好于术前。LASIK治疗组1眼因角膜上皮植入使最佳矫正视力较术前下降3行，其余眼最佳矫正视力均好于术前。

结论：PRK术中应用0.02g/L的MMC 30s治疗低、中度近视同LASIK具有同样的视力结果，避免了LASIK瓣的并发症，不失为一个可取的手术程序。

METHODS: Fifty-seven eyes of 30 patients with mild-to-moderate myopia were treated with PRK, and theLMMC was administered topically for 30 seconds. Seventy-seven eyes of 39 patients with mild-to-moderate myopia were treated with LASIK. The follow-up was evaluated 6 months later. Independent samples t test, Chi-square test were used for statistical analysis. Significance level was set P<0.05.

RESULTS: In the PRK+LMMC group 6 months later, mean spherical equivalent refraction was 0.210±0.72D, spherical equivalent refraction within ±0.50D was obtained in 71.9% of eyes, uncorrected visual acuity≥1.0 was obtained in 77.2% of eyes, and mean best spectacle-corrected visual acuity was 1.19±0.18, and they were-0.017±0.81D, 70.1%, 72.7% and 1.16±0.19, respectively, in the LASIK group 6 months later. The differences between two groups were not statistically significant(t=1.76; χ²=0.051; χ²=0.805; t=0.984, all P>0.05). No eye presented more than grade 1 haze in PRK+LMMC group. 1 eye occurred epithelial ingrowth in LASIK group.

CONCLUSION:PRK correcting mild-to-moderate myopia with LMMC administered topically for 30 seconds intraoperatively is equally effective with LASIK, and avoids LASIK flaps complications. PRK is an effective alternative to LASIK.