方法：选择有视野缺损，眼压控制在18mmHg以下的青光眼患者。符合入选标准者共29例48眼，男16例27眼，女13例21眼； 其中原发性开角型青光眼25眼，闭角型青光眼19眼，正常眼压性青光眼4眼。使用胞磷胆碱钠片，每次0.2g口服，每日3次连续用药3mo。观察用药前后视野的变化。分别于用药后1mo及3mo检测视野平均敏感度(MS)、平均缺损值(MD)和丢失方差(LV)等指标，并与用药前进行比较。

结果：用药1mo后48眼的平均视敏度值(MS)明显高于用药前，差异有统计学意义(P<0.01)； MD值明显低于用药前，差异有统计学意义(P<0.05)。用药3mo后，患者视野MS值明显高于用药前，差异有统计学意义(P<0.01)； MD和LV值明显下降，差异有统计学意义(P<0.01)。

结论：胞磷胆碱钠对青光眼性视野损害有一定程度的保护作用。

METHODS: Glaucoma patients with visual field defects and intraocular pressure(IOP)< 18mmHg were chosen, totally 29 patients 48 eyes were selected, of which 16 cases were male, 27 eyes, 13 cases were female, 21 eyes; in which 25 eyes were with primary open-angle glaucoma; 19 eyes with angle-closed glaucoma, and 4 eyes with normal IOP glaucoma. Citicoline sodium tablets were used orally, each 0.2g 3 times daily, continuously for three months. The visual field mean defect(MD), mean sensitivity(MS)and loss variance(LV), and other indicators were detected before and 1 month, 3 months after treatment.

RESULTS: One month after treatment, the MS of 48 eyes was significantly higher than that before treatment, the difference was statistically significant(P<0.01); MD value was significantly lower than that before treatment, the difference was statistically significant(P<0.05). Three months after treatment, the MS of patients was significantly higher than that before treatment, the difference was statistically significant(P<0.01); MD and LV value decreased, the difference was statistically significant(P<0.01).

CONCLUSION: Citicoline sodium has protective effect on visual function of primary glaucoma to some extent.