曲安奈德抑制糖尿病白内障后囊混浊的研究

Clinical study of inhibition of triamcinolone acetonide on posterior capsule opacification in diabetic cataract surgery

摘要:

目的:研究曲安奈德预防糖尿病性白内障术后后囊膜混浊的疗效和安全性。方法:收集2007-03/2011-09在我院行白内障超声乳化+人工晶状体植入术的糖尿病患者173例296眼随机分为3组。A组（102眼）使用平衡盐液进行水分离,B组（93眼）使用稀释的曲安奈德液进行水分离,C组（101眼）使用稀释的曲安奈德液进行水分离联合前房冲洗。分别于术后1wk;1,3,6,12mo观察患者最佳矫正视力、晶状体后囊膜混浊（posterior capsular opacity,PCO）分级情况。结果:术后1wk时A组与B,C组,最佳矫正视力之间的差异有统计学意义（P＜0.05）。其余各时间点A,B,C组之间的差异无统计学意义（P>0.05）。术后A组与B,C组PCO分级差异有统计学意义（P＜0.01）。结论:曲安奈德进行水分离联合前房冲洗能有效降低糖尿病性白内障术后后囊膜混浊的发生率,且眼内使用较为安全。

Abstract:

AIM:To study efficacy and security of triamcinolone acetonide for the prevention of capsule opacification after cataract surgery of diabetic. METHODS:Totally 173 diabetic patients 296 eyes who received phaco +IOL in our hospital from March 2007 to September 2011 were randomly divided into three groups. Group A (102 eyes) received balanced salt solution, and group B (93 eyes) diluted triamcinolone acetonide liquid the water separator, C group (101 eyes) using a diluted triamcinolone acetonide water separation joint anterior chamber irrigation. After 1 week; 1, 3, 6, 12 months,the best-corrected visual acuity(BCVA), posterior capsule opacification (PCO) grading situation observed in patients. RESULTS:One week postoperatively, the difference between BCVA in group A and group B, C was statistically significant (P<0.05). The rest of time points, there was no significant difference betweengroups A, B and C(P>0.05). After surgery, PCO grading in group A had statistically significant difference compared with that in group B, C(P<0.01), PCO grading in group B and group C was lower than that in group A and PCO grading in group C was lower than that in group B (P<0.05 ).CONCLUSION:Water separation and anterior chamber wash of triamcinolone acetonide can effectively reduce the incidence rate of PCO after diabetic cataract surgery. 