目的：探讨绵阳市糖尿病(DM)患者中糖尿病视网膜病变(diabetic retinopathy,DR)患病率和相关因素。 方法：普查社区登记确诊的749例DM患者,通过询问和检查获得病史资料,采用眼底检查或眼底血管荧光造影确立DR诊断,并分别检测空腹血糖、糖化血红蛋白、血清脂联素。结果：DM患者749例中共确诊DR患者151例,DR的患病率为20.2%。非增殖型和增殖型DR分别为108例（71.5%）和43例（28.5%）。空腹血糖在DM、非增殖型糖尿病视网膜病变(NPDR)和增殖型糖尿病视网膜病变(PDR)患者中分别为7.86±0.93mmol/L,8.24±217mmol/L,8.35±3.89mmol/L,三者比较无明显差异（P＞0.05）。糖化血红蛋白和血清脂联素在这三类居民中测得的结果分别为 6.24%±1.34%,7.12%±1.51%,7.94%±1.75%和8.48±2.89mg/L,6.74±2.11mg/L,4.57±1.82mg/L,三者比较有明显差异。结论：在DM居民中DR患病率高,需密切监测DM患者的高糖化血红蛋白和低血清脂联素,以控制DR患病。

AIM:To investigate the prevalence and correlative factors of diabetic retinopathy (DR) in residents with diabetes mellitus(DM) in Mianyang. METHODS: Totally 749 cases with confirmed DM were enrolled. The data of disease history was collected by inquiry and examination. Examination of ocular fundus and/or fundus fluorescein angiography(FFA) were used to confirm the diagnosis of DR. Fasting sugar, glycosylated hemoglobin and serum level of adiponcetin were examined. RESULTS: Totally 151（20.2%）residents were identified with DR. The incidence of single and proliferative DR was 71.5%(108 cases) and 28.5%(43 cases), respectively. Fasting sugar was 7.86±0.93mmol/L, 8.24±2.17mmol/L, 8.35±3.89mmol/L in DM, single DR and proliferative DR residents, there were no statistical difference（P＞0.05）. Glycosylated hemoglobin and serum level of adiponectin were 6.24%±1.34%, 7.12%±1.51%, 7.94%±1.75% and 848±289mg/L,6.74±2.11mg/L,4.57±1.82mg/L respectively in residents with DM, single DR and proliferative DR, there were statistical difference of glycosylated hemoglobin and serum adiponectin level among three groups. CONCLUSION: The incidence of DR is high in residents with DM. High glycosylated hemoglobin and serum level of adiponcetin of DM patients should be closely monitored in order to control DR.

四川省科技厅基金资助项目(No. 2008SZ0201)