目的：探讨LASIK术后加用非甾体抗炎药对缓解术后干眼症的疗效。 方法：选择2010-10/11在青岛眼科医院行LASIK手术的近视66例132眼。并在术后常规用药基础上，左眼只使用人工泪液，右眼加用1g/L普拉洛芬滴眼液，进行自身对照研究。根据右眼滴用非甾体抗炎药频率不同，分为A组：4次/d（74眼）、B组：6次/d（58眼）。分别于术前、术后10d;1mo进行主观问卷调查、基础泪液分泌试验(SⅠt)、泪膜破裂时间(BUT)、角膜荧光素钠染色(FL)、虎红染色、角膜表面不规则指数(ISV)、角膜表面非对称性指数(IVA)。并对几组结果分别进行统计学分析。 结果：与对照眼比较，除ISV和IVA之外，A,B两组组内比较术后10d及1mo其余指标差异均有统计学意义。A,B两组组间比较，术后10d BUT和虎红染色的差异有统计学意义(P<0.05)。术后1mo各项指标差异无统计学意义。 结论：角膜地形图ISV和IVA对于LASIK术后干眼的诊断具有意义，但对于术后干眼治疗的疗效评价缺乏特异性；在LASIK术后加用非甾体抗炎药，能通过减轻术后炎症反应、延长泪膜破裂时间而有效的缓解术后早期的干眼症状；增加非甾体抗炎药的滴用频率并不能明显增加药效。

AIM: To evaluate the efficacy of non-steroidal anti-inflammatory drugs to relieve the symptoms of dry eye after laser-assisted in situ keratomileusis (LASIK). METHODS: Sixty-six patients (132 eyes) were involved and made a self-controlled study in Shandong Eye Institute from November to October 2010. Based on conventional treatment, only artificial tears drops was used for the left eye, and 1g/L Pranoprofen drops was added for the right eye. According to the frequency of the drops, they were divided into two groups, including group A (4 times/day)and group B (6 times/day). Subjective symptoms, Schirmer test(SⅠt), tear break-up time(BUT), fluorescein staining(FL), rose bengal staining, index of surface variance(ISV) and vertical asymmetry(IVA) were recorded and made a statistical analysis respectively before and 10 days, 1 month after surgery. RESULTS: Compared with the control eyes ,there was a statistically significant difference in all the indicators except ISV and IVA of 10 days after the surgery, and except FL, ISV and IVA of 1 month after the surgery in both group A and group B.There was a statistically significant difference in BUT and rose bengal staining of ten days after the surgery between group A and group B(P<0.05). There was no statistically significant difference in indicators 1 month after the surgery. CONCLUSION:The tendency of ISV and IVA from topography shows a great leap but less specificity to evaluation of dry eye after LASIK. Add with 1g/L Pranoprofen drops after LASIK surgery could relief the symptoms of the dry eye effectively though reduce the inflammation and prolong the tear BUT. Increasing the frequency of the non-steroidal anti-inflammatory drugs could not significantly raise the efficiency of the drugs.