探讨下泪点封闭术用于药物治疗效果不佳的重度干眼症患者的临床疗效。 方法：选择2010-01/2011-01在我院眼科门诊就诊的19例38眼使用人工泪液效果欠佳的中重度干眼症患者，采用下泪点封闭术进行治疗。分别于术前3d及术后1wk；3，6mo进行裂隙灯显微镜检查泪河高度、角膜荧光素染色、泪液膜破裂时间(BUT)、SchirmerⅠ试验(SⅠt)以观察临床疗效。 结果：术前干眼患者主诉多为干涩、异物感、视疲劳。术后患者上述症状明显减轻,甚至消失。与术前相比, 15例30眼荧光素染色角膜上皮点状着色消失,下睑缘明显有泪河线形成。与术前相比,BUT和SⅠt明显增加和延长。 结论：下泪点封闭术可明显改善干眼症患者的临床症状，增加眼表的泪液量，打破干眼症泪液分泌的恶性循环，对于药物治疗效果不佳的中重度干眼症患者是一种简便有效的方法。

To investigate the clinical effect of blockage of inferior lacrimal point for the treatment of moderate or severe dry eye syndrome. METHODS: Surgical treatment in blockage of inferior lacrimal point have been used in 19 cases(38 eyes) with moderate or sever dry eye syndrome who have less effect with artifitial tears in our department from January 2010 to January 2011,The height of lacrimal rivus,corneal fluorescein stain,tear film break-up time(BUT),SchirmerⅠtest(SⅠt) were checked by slit-lamp microscope at preoperative 3 days and postoperative 1 week,3 months,6 months. RESULTS:Preoperative dry eye patients complained of dryness, foreign body sensation, visual fatigue. Postoperative patients with these symptoms significantly reduced or even disappeared. Compared with preoperative, 15 cases (30 eyes) with fluorescein staining of corneal epithelial punctate coloring disappeared, and the lower eyelid formed tears River line. Compared with preoperation, BUT and SⅠt significantly increased and the extension. CONCLUSION:Sugery of blockage of inferior lacrimal point can significantly improve the clinical manifestations of dry eye syndrome, increase the tear volume of ocular surface, break the vicious circle of tear secretion, which is an effective and simple method for moderate or severe dry eye patients who can not receive good outcome from medication therapy.