观察1/3剂量光动力学疗法（photodynamic therapy, PDT）治疗急性中心性浆液性脉络膜视网膜病变（central serous chorioretinopathy, CSC）的短期疗效。 方法：选取急性CSC患者26例26眼，行单次1/3量维替泊芬（2mg/m2）进行PDT治疗，术前和术后1，4，12wk进行最佳矫正视力和OCT的检测，且于术前、术后4wk和12wk进行眼底荧光素血管造影（FFA），吲哚青绿血管造影（ICG）检查，观察治疗的有效性和安全性。 结果：术后1wk，26眼中有20眼（77%）视网膜下积液吸收，其余6眼（23%）视网膜下液部分吸收；术后4wk，26眼视网膜下积液全部吸收，22眼荧光渗漏完全消失，脉络膜血管高渗透性消失；术后12wk，26眼均病情平稳，无复发。治疗后1wk，最佳矫正视力从术前平均0.41升高至0.80。随访期间26眼均未见任何不良反应。 结论：1/3剂量PDT治疗急性 CSC短期内安全有效

To evaluate the efficacy of photodynamic therapy (PDT) after 1/3 dose verteporfin injection to treat acute central serous chorioretinopathy (CSC). METHODS: Twenty-six eyes of 26 cases diagnosed with acute CSC by fundus fluorescein angiography(FFA) and optical coherence tomography (OCT) examination received one single session of PDT using 1/3 dose (2mg/m2) verteporfin. Best-corrected visual acuity (BCVA) was measured before, 1 week, 4 weeks, and 12 weeks after PDT with 1/3 dose. OCT, FFA and indocyanine green(ICG) examination were performed before, 4 weeks, and 12 weeks after PDT with 1/3 dose. RESULTS:Twenty of 26 eyes (77%) had complete resolution of subretinal fluid (SRF) 1 week after 1/3 dose PDT treatment. After 4 weeks, SRF in 26 eyes was completely absorbed, fluorescein leakage of 22 eyes reduced in FFA and the tortuous choroidal vessels appeared normal in ICG; Twelve weeks after PDT, there was no recurrence of CSC in 26 eyes. The mean BCVA was improved from 0.41 to 0.80 1 week after PDT treatment. CONCLUSION: PDT with 1/3 dose verteporfin injection is effective and safe in treating acute CSC