目的：观察角膜塑形术(orthokeratology)在控制或减缓不同屈光度青少年近视发展作用方面的差异。 方法：选用美国欧普康视角膜塑形镜(OK contact lens)，屈光度为-1.00～-5.00DS（等效球镜）、散光度≤-1.50DC的169例316眼青少年近视患者进行矫正后，依据屈光度平均分为4组，Ⅰ组-1.00～-2.00DS,Ⅱ组-2.25～-3.00DS,Ⅲ组-3.25～-4.00DS,Ⅳ组-4.25～-5.00DS，在6，12，24mo后，根据裸眼视力≥1.0和≥0.8的患者结果进行统计分析。 结果：配戴角膜塑形镜6mo后：Ⅰ组和Ⅱ组的裸眼视力≥1.0分别为100%和96.2%，Ⅲ组≥1.0的93.6%, Ⅳ组≥1.0的88.6%。在配戴12mo后：Ⅰ组≥1.0的87.3%,≥0.8的12.7%；Ⅱ组≥1.0的84.8%,≥0.8的15.2%；Ⅲ组≥1.0的77.2%,≥0.8的22.8%；Ⅳ组≥1.0的709%,≥0.8的29.1%。在24mo后：I组≥1.0的59.5%，≥0.8的15.2;Ⅱ组≥1.0的54.4%,≥0.8的19.0%；Ⅲ组≥1.0的53.2%,≥0.8的13.9%；Ⅳ组≥1.0的456%，≥0.8的10.1%。 结论：角膜塑形术在控制或减缓青少年近视发展的效果与配戴患者的屈光度增加成负相关，在中低度组配戴患者中，控制或减缓近视发展的效果优于高度组，因此对于早期中低度近视的青少年可以选择角膜塑形术，角膜塑形术在控制或减缓青少年近视方面具有起效快、无创性及塑形可逆的优点,在控制或减缓青少年近视发展方面是一种可以选择的方法。

AIM:To observe differences of orthokeratologys functions in controlling or slowing down the development of myopia for teenagers myopia with different diopter. METHODS: After correcting those myopia teenagers with spherical equivalent refraction between -1.00--5.00 D and astigmatism no more than -1.50 D by OK contact lens,169 cases (316 eyes) of myopes were divided into four groups according to the degree of refraction: Ⅰ(dioptre :-1.00--2.00DS), Ⅱ(dioptre : -2.25--3.00DS), Ⅲ(dioptre : -3.25--4.00DS), Ⅳ(dioptre : -4.25--5.00DS) myopic groups. They were followed up at 6, 12, 24 months after wearing glasses. Then results of groups with uncorrected visual acuity over 1.0 and 0.8 were analyzed statistically. RESULTS: Six months after wearing glasses, the ratios of groupⅠ,Ⅱ,Ⅲ and Ⅳ with uncorrected visual acuity over 1.0 were 100%, 96.2%, 93.6% and 88.6% respectively.12 months after wearing glasses, the ratios of groupⅠ,Ⅱ, Ⅲ and Ⅳ with uncorrected visual acuity over 1.0 were 87.3%, 84.8%, 77.2% and 70.9% respectively. Accordingly, the ratios of groupⅠ,Ⅱ,Ⅲ and Ⅳ with uncorrected visual acuity between 0.8 and 1.0 were 12.7%, 15.2%, 22.8% and 29.1% respectively. 24 months after wearing glasses, the ratios of groupⅠ,Ⅱ,Ⅲ and Ⅳ with uncorrected visual acuity over 1.0 were 595%,54.4%,53.2% and 45.6% respectively. Accordingly, the ratios of groupⅠ,Ⅱ,Ⅲ and Ⅳ with uncorrected visual acuity between 0.8 and 1.0 were 152%, 19.0%, 13.9% and 10.1% respectively. CONCLUSION: The results suggest negative correlation between the degree of myopia and the effect of orthokeratology in controlling or slowing down the development of teenagers myopia. Orthokeratology is more effective in group with medium myopia and low myopia than that in group with high myopia. Therefore, its more appropriate for myopia teenagers with early medium myopia and low myopia using orthokeratology. It has advantages such as fast-acting, non-invasive and reversible and can be used in controlling or slowing down the development of teenagers myopia.