目的：探讨在经鼻内镜泪囊鼻腔吻合术中应用丝裂霉素C治疗慢性泪囊炎的疗效。 方法：收集57例63眼慢性泪囊炎患者，在经鼻内镜泪囊鼻腔吻合术中应用丝裂霉素C，观察其临床疗效。 结果：术后随访6mo以上，治愈54例59眼（95%）；好转3例4眼（5%），总有效率100%。 结论：在经鼻内镜泪囊鼻腔吻合术中局部应用丝裂霉素C治疗慢性泪囊炎，治愈率高，面部不留瘢痕，出血少，泪囊定位准确，同时丝裂霉素C能有效抑制创面肉芽组织生长和纤维瘢痕形成，减少术后吻合口闭锁，提高手术成功率，是一种安全有效的治疗方式。

AIM:To discuss the clinical effect of mitomycin C in nasal endoscopic dacryocystorhinostomy for curing chronic dacryocystitis. METHODS:Totally 57 cases(63 eyes) with chronic dacryocystitis were performed the nasal endoscopic dacryocystorhinostomy combined with mitomycin C. The clinical effect was observed. RESULTS:All the patients were followed up for more than six months，54 cases (59 eyes, 95%) were cured，3 cases (4 eyes, 5%) were improved. Effectiveness was 100%. CONCLUSION:The application of mitomycin C in nasal endoscopic dacryocystorhinostomy is a safe and effective way to treat the chronic dacryocystitis.Because it possesses the advantages of higher cure rate，no scars of face and little hemorrhage and accurate location， at the same time, mitomycin C can prevent the growth of granulation tissue and the formation of fibrous scar，and reduce the atresia of ostomy，so it can increase the success rate of operation.