目的:研究广西地区壮族和汉族正常成年人（20~60岁）视盘参数正常值及其形态特征，比较其在不同民族间的差异。 方法:将3代居住广西隆林县无血缘关系的240例正常人（壮、汉族各120例480眼）纳入研究。运用海德堡视网膜断层扫描仪(Heidelberg retina tomograph-Ⅱ，HRT-Ⅱ)分别检测不同年龄段壮族与汉族人群视盘参数，并探讨民族、性别、眼别、年龄与视盘参数的关系。视盘参数包括视盘面积(DA mm²)、视杯面积(CA mm²)、视杯／视盘面积比值(C／DAR)、盘沿/视盘面积(R／DAR)、盘沿面积(RA mm2)、视乳头轮廓线高度变化值(HVC mm)、视杯容积(CV mm³)、盘沿容积(RV mm³)、平均视杯深度(MCD mm)、最大视杯深度(MxCD mm)、视杯形态测量(CSM mm)、平均视网膜神经纤维层厚度mRNFLT mm)、视网膜神经纤维层截面面积(RNFLA mm²)。 结果:按年龄分成4组，两民族间比较：CA、C/D，R/D，MCD，MxCD参数在30~39岁组有显著差异(P＜0.05)，RA参数在50~59岁组有显著差异(P＜0.05)，其余参数在各年龄段无显著差异。正常壮、汉族人mRNFLT和RNFLA值与年龄均呈负相关，壮族相关系数分别为-0.213和-0.186，汉族相关系数分别为- 0.233和-0.219，性别间各参数差异无显著意义，眼别间差异无显著意义。壮族C/DAR比值双眼差值范围为0.000~0.162。汉族C/D AR比值双眼差值范围为为0.048～0.112。 结论:两民族视乳头地形图参数无显著差异。年龄对视乳头地形图某些参数有一定影响，而性别间、眼别视盘各参数间差异无显著意义。

AIM: To compare multiple visual disc parameters and the retinal morphology of healthy Zhuang adults with healthy Han adults. METHODS: Two equal cohorts of 120 healthy adults (480 eyes) of Zhuang and Han ancestry aged 20 to 60 years from unrelated families residing in Longlin County, Guangxi Zhuang Autonomous Region, China, for at least three generations were enrolled in this study. The visual disc parameters in Zhuang and Han populations were determined in four different age brackets (20-29, 30-39, 40-49, and 50-59) using Heidelberg retinal tomograph-II (HRT-II), and the relations between these parameters and race, gender, eye (left/right), and age were evaluated. The evaluated visual disc parameters included disc area (DA mm²),cup area(CA mm²),cup/disc area ratio(C/DAR), rim/disc area ratio (R/DAR), rim area (RA mm²), height variation contour (HVC mm), cup volume (CV mm³), rim volume (RV mm³), mean cup depth (MCD mm), maximal cup depth (MxCD mm), cup shape measure (CSM mm), mean retinal nerve fiber layer thickness (mRNFLT mm)and retinal nerve fiber layer area(RNFLA mm²). RESULTS: There were significant difference in C/A, C/D, R/D, MCD, and MxCD between the ethnic two populations in the 30-39 year group (P<0.05), and a significant difference in RA between the 50-59 year age groups(P<0.05).No other statistically significant differences were observed for any other parameters. For both Zhuang and Han adults, mRNFLT and RNFLA were negatively correlated with age (correlation coefficients: -0.213 and -0.186 in the Zhuang population, -0.233 and -0.219 in the Han population). No statistical significance in these parameters was observed between males and females or between right and left eyes of the two ethnic populations. The C/DAR ratio difference between the left and right eyes ranged from 0.000 to 0.162 in the Zhuang population and from 0.048 to 0.112 in the Han population. CONCLUSION: There are few significant differences in optic papilla contour parameters between healthy Zhuang and Han adults, except for the 30-39 age group, and there is no statistical difference in these visual disc parameters by gender or eye between the two populations.

广西科学基金项目(No.桂科回0731011)