复方樟柳碱治疗青少年急性视神经炎的疗效观察

Clinical research on application of compound anisodine in adolescent patients with acute optic neuritis

摘要:

目的：观察应用复方樟柳碱注射液、激素冲击及补充能量综合治疗青少年急性视神经炎的疗效。 方法：将65例82眼青少年急性视神经炎患者随机分为两组，治疗组33例41眼，对照组32例41眼；治疗组在与对照组同样的全身用药的同时，于患眼颞浅动脉旁注射复方樟柳碱注射液，1次/d，2mL/次，于14，30，60d观察两组患者治疗前后病程时间、视力、视觉诱发电位及眼底荧光血管造影的变化。 结果：于14，30，60d观察两组患者治疗后的疗效，治疗组均比对照组的有效率高，两组比较差异有统计学意义(P<0.05)。 结论：加用复方樟柳碱颞浅动脉旁注射较传统激素冲击及补充能量综合治疗青少年急性视神经炎，可以缩短病程，减小激素用量，提高患者视力。

Abstract:

AIM:To observe the application of compound anisodine injection,hormone impact and supplemental energy comprehensive treatment of adolescents with acute optic neuritis. METHODS:Sixty-five cases (82 eyes) adolescent patients with acute optic neuritis were randomly divided into 2 groups:a treatment group of 33 cases (41 eyes) and a control group of 32 cases (41 eyes). At the same time, as the treatment group and control group were treated with the same systemic medication, the affected eyes in the treatment group were injected with compound anisodine around superficial temporal artery, 1 time a day, 2mL each time, In 14, 30, 60 days,the changes in course time, visual acuity, visual evoked potentials and fundus fluorescein angiography were observed before and after treatment in 2 groups. RESULTS: In 14, 30, 60 days, the efficacy observed in treatment group was higher than that in the control group,the difference was statistically significant (P<0.05). CONCLUSION:Combination with compound anisodine injection beside the superficial temporal artery for adolescents with acute optic neuritis can shorten the disease course, reduce the amount of hormone, and increase the patient’s visual acuity more than traditional hormone impact and supplemental energy comprehensive treatment.