目的：观察糖尿病小鼠视网膜血管内白细胞淤滞和细胞间黏附因子-1(ICAM-1)在视网膜的表达。 方法：选取C57型小鼠45只，随机分为2组：糖尿病组22只、正常组23只。10wk后取视网膜，荧光显微镜计数小鼠全视网膜微血管内淤滞的白细胞数目及其含有ICAM-1表达的荧光小球数目，免疫蛋白印迹法检测视网膜血管内皮生长因子(VEGF)和ICAM-1的表达。 结果：10wk后，糖尿病小鼠视网膜血管内白细胞数目及含有ICAM-1表达的荧光小球数目明显高于正常对照组（P<0.01）,其视网膜内VEGF和ICAM-1明显增加，有统计学意义(P<0.05)。 结论：视网膜血管内白细胞淤滞与糖尿病视网膜病变（DR）早期的视网膜毛细血管无灌注有关。

AIM: To investigate the leukostasis and expression of ICAM-1 in 10 weeks diabetic mice retina. METHODS:Forty-five C57 mice (20-25g) were randomly divided into two groups. There were twenty-two mice in diabetic group and twenty-three mice in normal group. The leukostasis in diabetic retinopathy was counted and the expression of VEGF and ICAM-1 was studied by Western Blot. RESULTS: Ten weeks postoperatively, the number of leukocyte was significantly high in diabetic retinopathy （P<0.01）.The expression of VEGF and ICAM-1 was significantly increased in diabetic group (P<0.05). CONCLUSION: The no perfusion of retinal blood capillary is related to leukostasis in early diabetic retinopathy.