高血糖诱发氧化应激可引起糖尿病视网膜病变（diabetic retinopathy,DR）中的周细胞凋亡。哺乳动物6个过氧化物酶（peroxiredoxin1-6,PRDX1-6）是一新的抗氧化蛋白家族，通过控制活性氧（reactive oxygen species,ROS）的水平负性调节氧化应激引起的细胞凋亡。我们就TAT介导的PRDX5，6蛋白转导防止高葡萄糖诱发视网膜周细胞的毒性作用作一综述。

Hyperglycemia-induced oxidative stress can cause pericytes apoptosis seen in diabetic retinopathy(DR). The six mammalian peroxiredoxins1-6 (PRDX1-6) are a new family of antioxidant proteins, which negatively regulate oxidative stress-induced apoptosis by controlling the level of reactive oxygen species (ROS).This paper reviewed the TAT-mediated PRDX5,6 protein transduction protects against high-glucose-induced cytotoxicity in retinal pericytes.