AIM:To evaluate the value of puncture of anterior chamber(PAC) in the treatment of high intraocular pressure(HIP) persistent status.METHODS:Thirty-eight eyes in HIP status of 38 patients whose IOP could not be reduced effectively with conventional drug treatment received treatment of PAC.RESULTS:All patients treated by PAC got symptomatic relief,including low intraocular pressure,easement of ophthalmalgia and headache,improvement of eyesight in varying degrees and average IOP of 17mmHg.CONCLUSION:Puncture of anterior chamber is an effective and safe clinical treatment to high intraocular pressure persistent status.It can quickly reduce IOP and alleviate the suffering of patients,protect the function of vision caused by the high lOP and also cut down incidence of drug side effect.