[关键词]
[摘要]
转化生长因子-β(TGF-β)作为一种生长因子,在角膜纤维修复反应中发挥的生物学效应和作用机制成为近年来研究的热点。TGF-β可通过Smad等信号传导通路调控修复细胞的生物学行为,充分发挥角膜基质细胞促进细胞增殖、细胞外基质形成、诱导细胞移行的正效作用。我们就TGF-β的概况、分子结构、TGF-β受体、信号传导通路、眼前节的分布、在角膜上的生物学功能以及在准分子激光屈光性角膜手术愈合中的研究作一综述。
[Key word]
[Abstract]
Recently,it becomes a hot study focused on transforming growth factor-β(TGF-β),as a kind of cytokine,whose biological effect and mechanism of action play an important role in corneal fibrosis and healing after surgery especially in excimer laser refractive surgery.Through some signal transduction passageway such Smad,TGF-β plays positive effect on accelerating cell proliferation,promoting extracellular matrix formation and inducing cell migration.Now we review TGF-β about its structure,receptor,signal transmission,distribution in eye,biological action and its relationship with corneal wound healing for excimer laser refractive surgery.
[中图分类号]
R779.63
[基金项目]
