目的:观察准分子激光角膜原位角膜磨镶术(LASIK)后角膜上皮植入及内生发生的情况,分析发生的原因和治疗方法。方法:我院自2006-09/2011-11行LASIK术2666例5212眼,其中发生角膜上皮植入及内生10例16眼,分析其发生的原因,采用不同的处理方法,并观察其疗效。结果:患者2666例5212眼中发生角膜上皮植入及内生的10例16眼,发生率为0.31%,按照发生的原因、时间、范围的大小及位置,采取不同的处理措施。其中4例5眼给予百力特眼液点眼,并辅予局部预防性降眼压药物点眼,角膜上皮植入及内生消失;6例11眼药物治疗联合手术掀瓣刮除层间上皮,并常规配戴绷带型角膜接触镜1～2d,术后予百力特眼液点眼,并辅予局部预防性降眼压药物点眼,所有患者随访6mo～4a无1例复发,视力恢复好。结论:LASIK术后角膜上皮植入及内生是术后所特有的并发症。术前要严格排除手术禁忌证,术中行规范手术操作、术后及早发现角膜上皮植入及内生并给予积极治疗是对LASIK术后并发症的有效治疗手段。

AIM:To investigate the treatments of epithelial ingrowth(EI)after laser in situ keratomileusis (LASIK),analyse the related factors,and evaluate efficacy of the treatment.METHODS:Ten patients (16 eyes) with EI were analyzed from 2666 paients(5212 eyes) who underwent LASIK from September 2006 to November 2011 in our hospital.The reason for occurrence of EI aftere LASIK was analyzed,the different treatment methods were used,and their efficacy was evaluated.RESULTS:The incidence rate of EI was 0.31% in 2666 paients(5212 eyes);According to the occurrence reasons,the occurrence time,the range and position,the different treatment methods were used.Four paients(5 eyes)were treated with 10g/L Prednisolone Acetate Ophthalmic Solution (Pred Forte)and intraocular pressure-lowering ophthalmic solution,EI disappeared;other six paients (11 eyes)were treated with pharmaceutical and surgery.The EI were cleaned up,and the corneal flap was dried in the open air for 1minute after repositioning the flap,and contact lens were used for 1-2 days after surgery.They were treated with Pred Forte and intraocular pressure-lowering ophthalmic solution after surgery.All paients had good visual acuity and no recurrence occured in the six months to four years follow-up.CONCLUSION:EI after LASIK is an special complication.Excluding contraindication preoperatively,operating normatively,early diagnosis and active treatment are effective treatment methods for EI.

R779.63