目的:探讨人工泪液(泪然)联合重组牛碱性成纤维细胞生长因子(贝复舒)滴眼液治疗青光眼滤过术后干眼的临床疗效。方法:选择青光眼滤过术后有干眼症状的患者60例60眼,随机分为治疗组和对照组两组,每组30例30眼,治疗组采用人工泪液和重组牛碱性成纤维细胞生长因子滴眼,对照组单用人工泪液。记录患者用药前和用药后2,4wk的干眼症状评分,裂隙灯下观察泪膜破裂时间(BUT)、泪液分泌试验(SⅠt)、角膜荧光素染色(FL)情况。结果:治疗前两组干眼症状评分,BUT,SⅠt,FL差异均无统计学意义(P>0.05),用药后2,4wk治疗组干眼症状评分,BUT,SⅠt,FL与对照组比较,差异均有显著统计学意义(P<0.01)。结论:人工泪液联合重组牛碱性成纤维细胞生长因子滴眼液治疗青光眼滤过术后干眼疗效优于单用人工泪液,效果显著。

AIM:To discuss the clinical effects of artificial tears and recombinant bovine basic fibroblast growth factor (rb-bFGF) eyedrops on dry eye after glaucoma filtering surgery.METHODS:All 60 cases(60 eyes)with dry eye symptom after glaucoma filtering surgery were chosen and randomly divided into two groups,treatment group and control group.In treatment group,the patients were treated by artificial tears and rb-bFGF eyedrops.In control group,the patients were treated by artificial tears.The subjective dry eye symptoms,fluorescein staining(FL),the time of tear secretion (Schirmer Ⅰ test,SⅠ t)and tear break-up time(BUT)were observed by slit lamp before treatment,2 weeks and 4 weeks after treatment.RESULTS:There was no statistical difference between the two groups before treatment (P>0.05).After treatment,the subjective dry eye symptoms,FL,S I t and BUT were significantly different (P<0.01).CONCLUSION:Artificial tears combined with rb-bFGF eyedrops can be effective to relieve the dry eye symptoms after glaucoma filtering surgery.

R779.6