目的:探讨丝裂霉素C(MMC)在青光眼小梁切除联合白内障囊外摘除人工晶状体植入术中的应用效果。方法:选择32例合并有青光眼的硬核白内障患者,随机分为MMC组及对照组,行小梁切除联合白内障囊外摘除人工晶状体植入术。其中MMC组术中使用0.2g/LMMC3min。比较两组在术后12mo内的并发症、手术效果及术后视力。结果:术后两组发生浅前房的几率无显著性差异。术后12mo时MMC组的功能性滤过泡为对照组的2倍,且有显著性差异。术后12mo,MMC组手术失败显著少于对照组,两组最佳矫正视力无显著性差异,且需行Nd:YAG后囊膜激光截开术的患者比例也无显著性差异。两组在随访期均未发生滤过泡渗漏、恶性青光眼以及眼内炎等并发症。结论:MMC可在一定程度上增加青光眼滤过联合白内障囊外摘除人工晶状体植入三联手术的成功率,且没有增加并发症的发生率。

AIM:To investigate the effect of mitomycin C in the surgery of trabeculectomy combined with extracapsular cataract extraction and IOL implantation.METHODS:Thirty-two patients with glaucoma and cataract were chosen and randomized to two groups,mitomycin group and control group.Both of the two groups were performed trabeculectomy combined with extracapsular cataract extraction and IOL implantation.0.2g/L mitomycin C was used for 3minutes in the mitomycin group.The complications,operative effect and postoperative visual acuity were compared 12 months after surgery.RESULTS:There were no significant differences in shallow anterior chamber,best corrected visual acuity and patients who needed Nd:YAG posterior capsulotomy in two groups,but the incidence of functional filter bleb in mitomycin group was significant more than that of control group,and the failure of the surgery in mitomycin group was significant less than that of control group.Both groups had no bleb leak,malignant glaucoma or endophthalmitis in follow-up.CONCLUSION:Mitomycin C can certainly increase the success of triple surgery without increasing the incidence of complications.

R779.6