目的:探讨翼状胬肉切除联合使用丝裂霉素C(mitomycin C,MMC)术后巩膜溶解的发生机制及预防、治疗。方法:对2006-11/2010-12我院门诊及住院翼状胬肉切除联合MMC术后巩膜溶解10眼患者进行追踪观察,并通过局部药物或手术方法进行治疗。结果:所有患者病变位于原翼状胬肉切除部位,且局部表现为组织缺血、变薄,部分患者病变区域可透见深层色素膜。通过局部药物或手术治疗,病情得到控制,且在随访期间无复发。结论:翼状胬肉切除手术为降低复发率,可采用联合MMC治疗,但是在MMC的浓度及作用时间上应慎重选择,并且术中应尽量减少局部组织的烧灼,以保证局部的血液供应,预防巩膜溶解的发生。

AIM:To discuss the mechanism,prevention and therapy of the scleral melting after pterygium excision with intraoperative application of mitomycin C(MMC).METHODS:Ten eyes with scleral melting after pterygium excision with MMC were followed up and treated with topical medicine or surgery.RESULTS:The ischemic,thinning could be found at the tissue where the pterygium was excised,and the deep pigment tissue appeared in some patients.The topical medicine and surgery were adopted according to the severity of melting.No recurrences were found during the follow-up.CONCLUSION:To reduce the recurrences after the pterygium excision,the assistant MMC treatment can be adopted,but the concentration and the duration of application should be considered,and the overdose of cauterization should be avoided to assure the enough blood supply at the wound.

R779.6