目的:观察人工泪液联合贝复舒眼用凝胶治疗眼睑刷上皮病的疗效。方法:观察86例172眼眼睑刷上皮病患者,分为治疗组43例和对照组43例。治疗组予以不含防腐剂的3g/L玻璃酸钠滴眼液和重组牛碱性成纤维细胞生长因子眼用凝胶(贝复舒眼用凝胶),对照组仅予以3g/L玻璃酸钠滴眼液点眼,3wk后复查。分别于治疗前后进行干眼评估问卷调查评分;荧光素和丽丝胺绿双染色,观察眼睑刷区的病变情况,据病变程度评分。比较两组治疗前后的差异。结果:治疗组治愈74眼(86%),好转12眼(14%),治愈率86%;而对照组治愈51眼(59%),好转34眼(40%),无效1眼(1%),治愈率59%,两组差异有统计学意义(P<0.05)。结论:人工泪液联合重组牛碱性成纤维细胞生长因子眼用凝胶治疗眼睑刷上皮病疗效显著。

AIM:To observe the clinical effect of lid-wiper epitheliopathy(LWE) treated by artificial tears combined with basic fibroblast growth factor(bFGF).METHODS:Eighty-six cases were divided into two groups randomly.The treated group were treated with preservative-free artificial tears(3g/L Hialid) combined with bFGF and the control group were treated with simple preservative-free artificial tears.After 3 weeks of treatment,all patients were rechecked.The observed indexes included lid-wiper staining(fluorescein and lissamine green dyes) and questionnaire survey of evaluation of dry eye.The difference of these indexes were compared between before and after treatment.RESULTS:The therapeutic effect of LWE in treated group was excellent in 74 eyes(86%),effective in 12(14%) and cure rate was 86%;versus therapeutic effect in control group was excellent in 51 eyes(59%),effective in 34 eyes(40%),ineffective in 1 eye(1%),and cure rate was 59%.There was statistically significant difference between the two groups(P<0.05).CONCLUSION:Artificial tears combined with bFGF play significant therapeutic effect in treating LWE.

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