角膜缘干细胞移植及羊膜移植联合丝裂霉素C治疗复发性翼状胬肉

Clinical effect of limbal stem cell transplantation combined with amniotic membrane transplantation and mitomycin C for the treatment of recurrent pterygium

摘要:

目的:研究角膜缘干细胞移植及羊膜移植联合丝裂霉素C治疗复发性翼状胬肉的临床效果。方法:收集复发性翼状胬肉47例54眼,随机分成A,B两组,均在显微镜下手术,A组行胬肉切除+羊膜移植术(24例28眼),B组行胬肉切除+角膜缘干细胞移植+羊膜移植联合丝裂霉素C(23例26眼),随访2a,观察术后复发情况。结果:A组治愈22眼,复发6眼,复发率21%,B组治愈25眼,复发1眼,复发率4%,采用SPSS统计字软件分析χ2=11.6452,P=0.0006,复发率有显著性差异,B组复发率明显低于A组。结论:角膜干细胞移植,羊膜移植联合丝裂霉素C治疗复发性翼状胬肉,术后复发率低,术后远期效果需进一步观察。

Abstract:

AIM:To study the clinical effect of limbal stem cell transplantation combined with amniotic membrane transplantation and mitomycin C for the treatment of recurrent pterygium. METHODS:Forty-seven patients (54 eyes) with recurrent pterygium were randomly divided into two groups:excision of pterygium and amniotic membrane transplantation being performed in group A(24 cases 28 eyes);excision of pterygium and limbal stem cell transplantation comined with amniotic membrane transplantation and mitomycin C being performed in group B (23 cases 26 eyes).All patients were performed the operation under microscope and had been followed up for two years. The recurrence rate was observed. RESULTS:Twenty-two eyes in group A were cured, 6 eyes recurred. Twenty-five eyes in group B were cured, 1 recurred. The recurrence rate was 21% in group A and 4% in group B. There was significant statistical difference between the two groups(χ2=11.6452,P=0.0006).The recurrence rate in group B was obviously lower than it in group A. CONCLUSION:Limbal stem cell transplantation combined with amniotic membrane transplantation and mitomycin C seems to be an effective treatment for recurrent pterygium, which has low recurrence rate.Futher research is necessary to observe the long term effect after surgery.