TA治疗外伤所致持续性黄斑水肿前后黄斑区功能的变化

The change of the function of macular area after intravitreal injection of triamcinolone acetonide for treatment of trauma induced persistent macular edema

摘要:

目的:探讨外伤性持续黄斑水肿患者玻璃体腔注射曲安奈德(triamicinolone acetonide,TA)治疗后黄斑区功能的变化。方法:外伤性持续黄斑水肿眼20例20眼,给予玻璃体腔内注射0.1mLTA。治疗后随访3mo,观察治疗前后视力、黄斑区神经上皮厚度、多焦视网膜电图(mfERG)N1,P1波的潜伏期和反应密度等变化情况。结果:治疗后3mo,矫正视力0.78±0.11,与治疗前(0.21±0.09)相比,差异有显著统计学意义(P<0.01)。治疗后3mo,黄斑区神经上皮平均厚度158.00±13.73μm,与治疗前(321.67±42.24μm)相比,差异有显著统计学意义(P<0.01)。治疗后3mo,mfERG1,2环N1,P1波潜伏期和反应密度与治疗前相比明显下降,差异有显著统计学意义(P<0.01)。结论:TA治疗外伤所致持续性黄斑水肿是一种有效的方法;水肿消退后黄斑区功能得到改善。

Abstract:

AIM:To evaluate the change of the function of macular area after intravitreal injection of triamicinolone acetonide for treatment of trauma induced persistent macular edema. METHODS:Twenty eyes with persistent macular edema induced by trauma were injected 0.1 milliliter triamicinolone acetonide into vitreous.Their visual acuity, thickness of nerve fibers layer of macular,incubation period and response densities of N1,P1 waves of the multifocal electroretinography were studied. RESULTS:After 3months’ treatment , their average visual acuity and thickness of nerve fibers layer of macular were 0.78±0.11 and 158.00±13.73μm;before treatment they were 0.21±0.09 and 321.67±42.24μm, incubation period and response densities of the N1,P1 waves of multifocal electroretinography’ s 1 and 2 rings decreased. Compared with those before treatment, there were significant statistical difference(P<0.01). CONCLUSION:Intravitreal injection of triamcinolone acetonide is a safe and effective way to treat the persistent macular edema induced by trauma, the function of macular area improve after edema dismissing of macular area.