目的:评价二性霉素B溶液前房冲洗治疗深层真菌角膜炎的临床疗效。方法:选取我科2006-02/2010-02治疗的深层真菌性角膜炎患者42例42眼,随机分为两组,实验组局部及全身应用氟康唑联合应用二性霉素B溶液进行前房冲洗治疗;对照组局部及全身应用氟康唑并应用9g/L氯化钠注射液进行前房冲洗治疗。观察溃疡面的愈合、前房积脓的吸收、视力情况及其他并发症的情况。结果:实验组与对照组溃疡面愈合的情况比较,P=0.001;前房积脓吸收的情况比较,P=0.003,均具有统计学意义。治疗前后视力情况比较,P=0.300,其差异无统计学意义。结论:二性霉素B溶液前房冲洗治疗深部真菌角膜炎缩短了溃疡愈合及前房积脓吸收的时间,减少了并发症的发生。

AIM:To evaluate the clinical curative effect of irrigating the anterior chamber with solution of amphotericin B to treat the fungal keratitis. METHODS:Forty-two patients(42 eyes) were included in this study.The patients were randomly divided into two groups. One was experimental group:the treatment included local and systemic application of fluconazole and combination of irrigating the anterior chamber with solution of amphotericin B.The other was control group:local and systemic fluconazole was used,irrigating the anterior chamber with 9g/L sodium chloride injection. Ulcer healing,hypopyon absorption, vision and other complications were observed. RESULTS:The data of ulcer healing of experimental group and control group were compared, the result was P=0.001. The data of hypopyon absorption of experimental group and control group were compared, the result was P=0.003. They had statistical significance.The data of vision of the patients before and after the treatment were compared, the result was P=0.300, the difference had no statistical significance. CONCLUSION:Irrigating the anterior chamber with solution of amphotericin B to treat the fungal keratitis reduces fungal keratitis ulcer healing and hypopyon absorption time and the complications.

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