早产儿视网膜病变模型研究进展

Research progress in model of retinopathy of prematurity

摘要:

目前,早产儿视网膜病变(retinopathy of prematurity,ROP)已经成为世界范围内儿童致盲的重要原因,约占儿童致盲原因的6%～18%。防治ROP以改善早产儿的生存质量已成为全球关注的焦点。因此,建立合适的视网膜新生血管动物模型已成为探讨视网膜新生血管的发生机制并评估其药物治疗效果的重要手段。本文对用各种模型模拟ROP的发生过程进行综述。

Abstract:

Currently, retinopathy of prematurity (ROP) has become a worldwide important cause of blindness in children, accounting for 6% to 18% of causes of blindness in children. It has become a global concern to improve the quality of life in preterm infants by controlling ROP. Therefore, the establishment of an appropriate animal model of retinal neovascularization has become an important means of discussing the pathogenesis of retinal neovascularization and assessing the effect of drug treatment. In this paper, a variety of models to simulate the process of ROP were reviewed.