渗透压在白内障形成过程中的研究进展

Advances in studies on effects of osmotic pressure in occurrence of cataract

摘要:

白内障是当今世界范围内的主要致盲眼病之一,其病理基础是晶状体的代谢异常以及晶状体混浊。目前的研究发现,渗透压的改变在晶状体的代谢过程中发挥重要作用,通过影响晶状体上皮细胞内的多元醇代谢路径(polyolpathway)、水通道蛋白(aquaporin)以及晶状体上皮细胞间的缝隙连接通道蛋白(gap junction proteins)等的改变,以影响晶状体的代谢,从而引起白内障。关于渗透压对晶状体代谢的作用及其机制作一综述。

Abstract:

Cataract is one of the main causes of blindness in the current world, pathological basis of cataract is abnormal metabolism of lens as well as lenticular opacification. So far,it has been found that changes of osmotic pressure play an important role in the phase of lens’ metabolism, which influence polyol pathway, aquaporin, and gap junction proteins in the lens epithelial cell. Eventually these changes can affect lens’ metabolism and lead to the formation of cataract. This study makes statesment in the mechanism of function and effectiveness of osmotic pressure on lens’ metabolism.