TGF-β/Smads信号传导通路在后发性白内障中的研究进展

Research progress of TGF-β/Smads signaling pathway on posterior capsule opacification

摘要:

后发性白内障(posterior capsular opacification,PCO)是现代白内障术后最常见的主要并发症之一。Smad蛋白家族是转化生长因子-β(TGF-β)细胞内信号传导的重要因子。TGF-β/Smads信号传导通路在PCO中起着至关重要的作用,特别是各类Smads在TGF-β2的诱导中与PCO存在密切关系。本文就TGF-β/Smads与PCO的关系作一综述。

Abstract:

The posterior capsule opacification(PCO)is one of the most mainly common complications after modern cataract surgery. Smad proteins family are important factors of intracellular TGF (transforming growth factor)-β signaling transduction. TGF-β/Smads signalling pathway is very important for PCO, especially all kinds of Smads are being close relationship with PCO in induction of TGF-β2.This article reviewed the relationship between TGF-β/Smads and PCO.