渗出性年龄相关性黄斑变性341例激光治疗效果分析(英文)

Laser treatment in 341 patients with exudative age-related macular degeneration

摘要:

目的:探讨渗出性年龄相关性黄斑变性( AMD) 患者激光治疗的预后。方法:前后比较,以评价治疗的有效性。结果:共纳入341 例392 眼渗出性 AMD 病例,其中77.6%伴有脉络膜新生血管( CNV) 。未使用吲哚氰绿( ICG) 血管造影时,仅在 1. 8% 患眼发现隐匿性 CNV; 而使用 ICG血管造影后,该比例提高到 19. 5% ( P < 0. 001) 。激光治疗后,共 349 眼进入随访,其中 68. 2% 视力保持稳定。经统计学检验,病变部位与治疗前后视力改变相关( P <0. 001) ,也与病变复发相关( P < 0. 05) 。在黄斑中心凹区病变的复发率小于旁中心凹或中心凹外病变。结论:ICG 血管造影对研究隐匿性 CNV 治疗效果相当重要。

Abstract:

AIM:To document the prognosis of laser treatment in patients with exudative age-related macular degeneration ( AMD) . METHODS:Efficacy of the intervention was evaluated using a before-after method. RESULTS:A total of 392 eyes of 341 patients with exudative AMD were examined. 77. 6% had choroideal neovascularisation ( CNV) . Before the use of indocyanine green ( ICG) angiography,occult CNV was detected in only 1.8% of the eyes,but after the use of ICG angiography,this increased to 19. 5% ( P < 0. 001) . Of the 349 eyes which were followed up,visual acuity had remained stable in 68.2% of the eyes. There was a statistically significant relationship between localization of lesion and visual acuity changes on pre-and post-laser treatment ( P < 0. 001) . Also there was a statistically significant relationship between localization of lesion and recurrence ( P <0.05) . The recurrence was less in subfoveal lesions than that in juxtafoveal and extrafoveal lesions. CONCLUSION:ICG angiography is highly important in the treatment of occult CNV.