IFN-α治疗白塞氏病葡萄膜炎的新进展

Progress in IFN-α treatment of uveitis caused by Behcet’s disease

摘要:

白塞氏病(Behcetsdisease,BD)是一种累及多系统、多器官的慢性、复发性、全身性疾病。由BD引起的葡萄膜炎是我国常见葡萄膜炎中重要的致盲类型,目前尚无根治方法。IFN-α是一种具有多种生物学效应的细胞因子,具有较强的免疫双向调节作用,近年来被应用于多种免疫性疾病的治疗。IFN-α的深入研究为白塞氏病葡萄膜炎的治疗带来了新的希望。

Abstract:

Behcet’s disease (BD) is a chronic, recrudescent, systemic disease which involves multi-system and multi-organ. Uveitis caused by BD is a common type of uveitis inducing blindness in China. There is no radical cure for this kind of uveitis at present. IFN-α is a kind of cytokine which has multiple biological effects. It has a dual immunomodulatory activity, and has been applied to a variety of immune diseases in recent years. In-depth study of IFN-α will bring new hope for uveitis caused by BD treatment.