目的:探讨在联合应用毛果芸香碱与噻吗心安两种抗青光眼滴眼液的不同给药方式中,能够达到最佳控制眼压效果的给药方式。方法:新西兰大耳白兔36只随机分为毛果芸香碱组、噻吗心安组、常规同时给药1组、常规同时给药2组、毛果+噻吗组、噻吗+毛果组,共6组,建立慢性青光眼高眼压模型。此6组分别于滴注生理盐水或第一次给药后10,20,30,40,60,90,120,150,180和240min测眼压,比较眼压变化情况。结果:毛果+噻吗组眼压下降幅度明显,差异具有统计学意义(P<0.05)。结论:滴注毛果芸香碱滴眼液30min后滴注噻吗心安滴眼液,控制青光眼眼压稳定,效果最佳。

·AIM:To study the joint application of the two anti-glaucoma medication—pilocarpine and timolol in different ways so as to find the best method of drug delivery and formulate the rational administration schedule.·METHODS:Experimental study.A total of 36 New Zealand white rabbits were randomly divided into six groups.They were control group,pilocarpine group,timolol group,the conventional-dose group 1,the conventional-dose group 2,pilocarpine + timolol group,and timolol + pilocarpine group.The ocular hypertension model of chronic glaucoma was established.After administering the saline or first drug delivery for 10,20,30,40,60,90,120,150,180,240 minutes,the intraocular pressure was measured to compare the changes.·RESULTS:Pilocarpine + timolol group had significant effect on the intraocular pressure reducing,with statistically significant difference(P<0.05).·CONCLUSION:The way of administering pilocarpine eye drops,and 30 minutes later administering the timolol eye drops,has the best effect on controlling the intraocular pressure than others.·

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中国江苏省科研创新计划资助项目