目的:评价激光术后应用复方樟柳碱治疗中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy,CSC)的疗效和预防复发的效果。方法:将156例158眼CSC患者分成两组,治疗组86例86眼采用激光联合复方樟柳碱治疗,对照组70例72眼采用氪黄激光联合复方丹参+肌苷治疗,比较两组在治疗效果和复发率方面的差异。结果:激光联合复方樟柳碱组治愈率为94.2%(81/86),平均治愈时间34.8±8.6d,复发5例5眼,占5.8%;激光联合复方丹参+肌苷组治愈率为75.0%(54/72),平均治愈时间68.4±16.8d,复发18例18眼,占25.0%。两组治愈率比较差异有显著统计学意义(P<0.01),两组总有效率的比较差异无统计学意义。平均治愈时间天数差异有显著统计学意义(P<0.01),复发率差异有统计学意义(P<0.05)。结论:氪黄激光联合复方樟柳碱治疗CSC安全、有效,对缩短病程、防止黄斑区光损伤的进展,并修复损伤的视网膜非治疗区,改善视网膜功能和降低复发率效果明显。

AIM:To evaluate curative effect of laser combined with compound anisodine for central serous chorioretinopathy(CSC).METHODS:All of 156 cases 158 eyes diagnosed with CSC were divided into two groups.Laser combined with compound anisodine was performed in 86 cases 86 eyes as treatment group;the control group,70 cases 72 eyes,were treated by krypton laser combined with danshen and inosine.The curative effect and recurrent rate were compared in two groups.RESULTS:The cure rate was 94.2% in treatment group,75.0% in control group;in treatment group the average cure time was 34.8±8.6 days,5 cases 5 eyes recurred,however in control group the average cure time was 68.4±16.8 days,18 cases 18 eyes recurred.There was statistically significant difference in the average cure time(P<0.01) and recurrent rate(P<0.05) between two groups.There was significant difference in cure rate in two groups(P<0.01).CONCLUSION:Krypton laser combined with compound anisodine for CSC is effective and safe.The effect which can shorten the course of disease,prevent the progress of photic injure in the macular area and repair the retinal non-treament area,improve the function of retina and reduce the recurrent rate is obvious.

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