目的:研究睫状体脉络膜上腔分离术联合硅胶带植入术对兔眼房水引流的影响。方法:新西兰大白兔12只,随机分为2组,每组6只,一组右眼行睫状体脉络膜上腔分离术联合硅胶带植入术,另一组右眼行标准小梁切除术,观察术后10,21,42d眼压及房水流畅系数的变化。结果:睫状体脉络膜上腔分离术联合硅胶带植入术组术后10d眼压下降(33.7±3.7)%,与小梁切除术组降压(32.2±3.8)%幅度一致(P=0.501);术后21d眼压下降(14.7±1.6)%,较小梁切除术组(2.3±9.1)%大(P=0.013),标准小梁切除术组21d左右眼压即恢复正常;术后42d眼压下降(0.3±7.9)%,与小梁切除术组(3.5±6.3)%无统计学差异(P=0.461)。房水流畅系数硅胶带植入术组术后10d为0.38±0.03,与小梁切除术组(0.35±0.03)无统计学差异(P=0.16);术后21d为0.26±0.03,较小梁切除术组(0.21±0.02)大(P=0.006);术后42d为0.18±0.02,与小梁切除术组(0.19±0.03)无统计学差异(P=0.765)。结论:兔眼睫状体脉络膜上腔分离术联合硅胶带植入术可有效降低兔眼眼压,增大兔眼房水流畅系数。

AIM:To investigate the effect of ciliochoroidal detachment combined with implantation of silica gel buckling band on aqueous outflow in rabbit eyes.METHODS:Two groups were set up from 12 rabbits,experimental ciliochoroidal detachment combined with implantation of silica gel buckling band was performed on 6 rabbits’ right eyes,each eye of the other 6 rabbits received trabeculectomy as control.At 10,21,42 days postoperatively,the intraocular pressure,coefficient of aqueous outflow facility(C-value) were observed.RESULTS:Ten days postoperatively,IOP decrease percentage was consistent between experimental ciliochoroidal detachment combined with implantation of silica gel buckling band group(33.7±3.7)% and trabeculectomy group(32.2%±3.8%,P=0.501).At postoperative day 21,in experimental group,IOP decrease percentage was(14.7±1.6)%,which was larger than that in trabeculectomy group(2.3%±9.1%,P=0.013),IOP returned to normal at 6th week postoperatively in experimental group,while at 21st day postoperatively in trabeculectomy group.At 10th day postoperatively,C-value was 0.38±0.03 in experimental group and 0.35±0.03 in trabeculectomy group(P=0.16),at 21st day postoperatively,it was 0.26±0.03 and 0.21±0.02(P=0.006),and at 6th week postoperatively,it was 0.18±0.02 and 0.19±0.03 respectively(P=0.765).CONCLUSION:Ciliochoroidal detachment combined with implantation of silica gel buckling band could effectively reduce IOP of rabbits,increase the C-value,and enhance the uveoscleral outflow.

R779.6

中国湖北省武汉市科技攻关课题资助项目(No.200852199600);中国湖北省华中科技大学自主创新研究基金资助项目(No.2010JC027)