目的:探讨光学相干断层成像术(OCT)与超声角膜测厚仪测量角膜厚度的统计学差异及临床意义。方法:选取2010-07/09在我院屈光矫治中心就诊的近视患者102例199眼,分别行OCT及超声测厚法测量角膜厚度,经统计学检验后进行分析。结果:患者199眼经OCT所得结果为532.478±29.49μm,超声测厚仪所得结果为541.47±29.00μm,行配对t检验(t=14.805,P=0.000),认为两种测量方法结果的差异有统计学意义。进一步以超声测厚结果为标准将角膜厚度分4组进行配对t检验,角膜厚度≤500μm时,OCT测量角膜厚度值(479.07±11.57μm)与超声结果(486.47±7.24μm)差异有统计学意义(P=0.002);500μm<角膜厚度≤550μm时,OCT测量角膜厚度值(520.34±12.56μm)与超声结果(529.16±12.41μm)差异有统计学意义(P=0.000);550μm<角膜厚度≤600μm时,OCT测量角膜厚度值(554.99±14.02μm)与超声结果(563.93±10.11μm)差异有统计学意义(P=0.000);角膜厚度(600μm时,因为例数太少未作比较。结论:传统的超声测厚与OCT对角膜测厚结果有一定差异,并具统计学意义,但在临床意义上二者仍有较好的相符性,可以作为准分子手术前的评估参考。

AIM:To investigate the clinical significance of corneal thickness measurement difference between optical coherence tomography(OCT)and corneal pachymeter.METHODS:The clinical data of corneal thickness in 102 cases 199 eyes measured by ultrasonic corneal hymeter and OCT were analyzed by statistical test.RESULTS:The thicknesses were 532.478±29.49μm and 541.47±29.00μm from OCT and ultrasonic corneal pachymeter respectively,there was statistical significance by paired t-test.It was divided into 4 groups by corneal thickness standardized on ultrasonic thickness measuring,paired t-test showed that when the corneal thickness≤500μm,500μm <corneal thickness≤550μm,550μm<corneal thickness≤600μm,there were all statistical significances between ultrasonic corneal pachymeter and OCT,when the corneal thickness>600μm,no comparison was done for little cases.CONCLUSION:Traditional ultrasonic corneal pachymeter and OCT showe some differences and better clinical conformance on measuring corneal thickness and can be used as reference before excimer laser surgery.

R779.63