目的:探讨糖尿病患者血清VEGF浓度变化与糖尿病患者糖化血红蛋白及糖尿病病程的关系。方法:符合本研究条件的糖尿病患者86例,采用双抗体夹心ELISA法检测血清VEGF浓度,HbA1c色谱分光光度计法测定糖化血红蛋白(HbA1c)水平,血糖(BS)取末梢指血检测空腹血糖(FBS)、餐后2h血糖(P2BS),记录糖尿病病程。结果:血清VEGF浓度与HbA1c和病程呈正相关性且具有显著性统计学意义(P<0.01),与空腹血糖、餐后2h血糖相关性无统计学意义。结论:糖尿病患者血清VEGF浓度与HbA1c和病程呈正相关性。

AIM:To explore the relationship between HbA1c and VEGF in the serum of patients with diabetes mellitus(DM).·METHODS:Eighty-six patients with DM were collected in the study. VEGF level in the serum was detected by using enzyme linked immunosorbent assay (ELISA) for quantitative analysis. HbA1c was measured by Chromatograph spectrophotometer. The course of DM was recorded.·RESULTS:The level of VEGF had a significant positive correlation with HbA1c in serum and course of DM(P<0.01),while it had no significant difference with FBS and P2BS.·CONCLUSION:The level of VEGF had a significant positive correlation with HbA1c in serum and course of DM.

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中国国家自然科学基金资助项目(No.30772373);中国陕西省自然科学基金资助项目(No.2006C213);中国西安市科技计划资助项目(No.GG06173)~~