增殖性视网膜病变,如增殖性糖尿病视网膜病变(proliferativediabeticretinopathy,PDR),早产儿视网膜病变(retinopathyof prematurity,ROP)等,是致盲的主要原因。这类疾病的病理特点是视网膜前血管过度生长,引发纤维瘢痕形成,最终导致视网膜脱离。这种不正常和不成比例的血管过度生成是一种代偿机制,用以克服早期阶段的微血管退化和恢复缺氧视网膜的代谢平衡。迄今为止,治疗方式很大程度上依赖于外科侵入性干预。在本篇综述中,我们以血管新生为中心,对这类疾病的发生机制和治疗策略进行深入讨论。

Proliferative retinopathies such as proliferative diabetic retinopathy(PDR) and retinopathy of prematurity(ROP), are the leading causes of blindness.These pathologies are characterized by excessive pre-retinal blood vessel growth that can ultimately lead to a fibrous scar formation and culminate in retinal detachment.This abnormal and disproportionate hyper-vascularization is a compensatory mechanism to overcome an earlier phase of microvessel degeneration and reinstate metabolic equilibrium to the hypoxic retina.To date,the treatment modalities to counter these diseases largely rely on invasive surgical interventions.In this review,tightly around the angiogenesis, we discuss the current views on mechanisms and available treatments and present future strategies to tackle these diseases.

R774.1

中国上海市卫生局科研基金资助项目(No.2009006)~~