目的:比较应用胰岛素泵持续皮下胰岛素输注法(continuoussubcutaneous insulin injection,CSII)与多次皮下胰岛素注射法(multiple subcutaneous insulin injection,MSII)对2型糖尿病(T2DM)眼病围手术期的血糖控制,探讨最佳血糖控制方法。方法:将320例拟行眼科手术的T2DM患者分为CSII组和MSII组,比较两组治疗前后血糖、达标时间、胰岛素用量、低血糖、术后并发症发生率、住院时间及费用。结果:两组均可有效控制血糖(P<0.01),治疗后CSII组餐后2h血糖(2hPBG)优于MSII组(P<0.01),CSII组血糖达标时间、胰岛素用量、低血糖及术后并发症发生率、住院时间均少于MSII组(P<0.01)。CSII组住院费用高于MSII组(P<0.01)。结论:T2DM眼病围手术期应用胰岛素泵安全有效,并可明显缩短住院时间,但住院费用有所增加。

·AIM:To compare the effect of continuous subcutaneous insulin injection(CSII)by using insulin pump and multiple subcutaneous insulin injection(MSII)in treatment of eye diseases in type 2 diabetes mellitus(T2DM)patients during the perioperation period.·METHODS:The study included 320 T2DM patients with eye diseases,who were divided into two groups randomly:CSII group and MSII group.The changes of some clinical indexes were compared between the two groups before and after treatment,including the plasma glucose levels,the duration to achieve the target for plasma glucose,insulin dosage,the incidence of hypoglycemia and complication,the length and expense of hospitalization.·RESULTS:The plasma glucose levels in both groups decreased evidently after the therapy(P<0.01).The plasma glucose 2 hours after meal in CSII group was lower than that in MSII group(P<0.01)with less insulin dosage(P<0.01).The duration to achieve the target for plasma glucose and the length of hospitalization in CSII group was shorter than those in MSII group(P<0.01).The incidence of hypoglycemia and complication was lower than those in MSII group(P<0.01).However,the expense of hospitalization in CSII group was higher than that in MSII group(P<0.01).·CONCLUSION:The insulin pump was safe and effective for T2DM patients with eye diseases during the peri-operation period.·