目的:观察苦碟子注射液治疗前部缺血性视神经病变(an-terior ischemic optic neuropathy,AION)的疗效。方法:临床确诊的AION患者32例32眼,其中16例16眼接受苦碟子注射液(沈阳双鼎制药有限公司)20mL静脉滴注治疗(治疗组);另外16例16眼接受丹参注射液(正大青春宝药业有限公司)20mL静脉滴注治疗(对照组)。均以15d为1个疗程。两组患者用药后每天观察视力、眼底变化,治疗前后均予视野检查。结果:治疗组视力提高程度明显好于对照组,两组间差异有统计学意义(P<0.01);用药第3,7,15d,治疗组视力提高程度明显好于对照组,其差异有统计学意义(P<0.01;P<0.05;P<0.01);治疗组中,14眼治疗后视野好转(87.50%);2眼无变化(12.50%)。对照组中,7眼治疗后视野好转(43.75%);9眼无变化(56.25%)。两组视野变化的差异比较有统计学意义(P<0.01)。结论:苦碟子注射液治疗AION安全有效。

AIM:To observe the therapeutic effect of kudiezi on anterior ischmic optic neuropathy(AION).METHODS:In 32 patients 32 eyes who were diagnosed as with AION,16 patients 16 eyes underwent intravenous drip with kudiezi 20mL (treatment group),and the other 16 patients 16 eyes underwent intravenous drip with dansen 20mL (control group) with the period of treatment of 15 days.The changes of visual acuity and ocular fundus of the patients after injection were recorded,and the visual field was checked before and after the treatment.RESULTS:The visual acuity was better in treatment group than that in control group with significant difference (P<0.01).At the 3rd,7th and 15th day after treatment,the visual acuity was better in treatment group than that in control group with significant difference(P<0.01;P<0.05;P<0.01).In treatment group,the visual field improved in 14 eyes (87.50%)and of remained unchanged in 2 eyes (12.50%).In control group,the visual field improved in 7 eyes(43.75%)and remained unchanged in 9 eyes (56.25%).There was significant difference between the two groups (P<0.01).CONCLUSION:Kudiezi is efficacious in treatment of AION.

R276.7