目的:研究黄芩苷对炎性视网膜水肿的影响。方法:建立炎性视网膜水肿的动物模型,用OCT测量黄芩苷对炎性视网膜水肿过程中视网膜厚度的影响。新西兰白兔15只(30个视网膜)随机分为5组,建立炎性视网膜水肿模型后,组1注射黄芩苷溶液(160mg/L,20mL/kg),2次/d;组2使用黄芩苷溶液(40mg/L,20mL/kg),2次/d;组3使用黄芩苷溶液(10mg/L,20mL/kg),2次/d;组4使用球后注射曲安奈德,给药剂量为20mg(0.5mL)。组5为对照组,被耳缘静脉注射等量BSS。分别在建模后1,2,4,6,10,14,21d用光学相干断层扫描(opitical coherence tomograph,OCT)测量视网膜的平均厚度。结果:与炎性对照组相比,黄芩苷治疗组视网膜厚度明显降低,两组差异具有统计学意义(P<0.01);黄芩苷组与激素组比较,48h内有差别,但差异不显著(t=5.85,4.3;0.001<P<0.01);2d后,两组差异性消失(t<2.447,P>0.05),从统计学角度看两者无差别。结论:黄芩苷能够有效抑制炎性视网膜细胞外水肿,并且与皮质激素具有相同的药效,并且无明显毒副作用。

AIM:To establish the inflammatory retinal edema animal model and research the influence of the baicalin on the inflammatory retinal edema.METHODS:Opitical coherence tomograph (OCT) was used to survey the effect of baicalin on the retina thickness in inflammatory retinal edema.15 inflammation-mediated rabbits were randomly assigned to five groups,each group included 3 rabbits(6 retinas),which received different treatments,respectively:baicalin(160mg/L,20mL/kg) by iv.administration bid;baicalin (40mg/L,20mL/kg) by iv.administration bid;baicalin (10mg/L,20mL/kg) by iv.administration bid;triamcinolone acetonide(TA) retrobulbar injection of 20mg respectively;the control group was injected physiologic saline in the same volume.The effect was measured by the thickness of retinas of OCT on day 1,2,4,6,10,14 and 21 respectively.RESULTS:Compared with the inflammatory control group,the thickness of baicalin group reduced apparently,the difference was remarkable(P<0.01),and the difference between baicalin group and TA group after 2 days were not statistically significant(t<2.447,P>0.05).CONCLUSION:The baicalin could suppress the inflammatory retina cell edema effectively,it even has the same drug efficacy with the TA,and no obvious poisonous side effect.

R285.5