自体角膜缘干细胞移植术治疗复发性翼状胬肉疗效观察

Limbal conjunctival autograft transplantation for recurrent pterygium

摘要:

目的:观察自体角膜缘干细胞移植术治疗复发性翼状胬肉疗效。方法:把66例81眼复发性翼状胬肉患者随机分为两组,治疗组:34例44眼行翼状胬肉切除联合自体角膜缘干细胞移植术;对照组:32例37眼行翼状胬肉切除联合带蒂结膜瓣转移术。胬肉复发的定义:血管纤维组织重新侵入角膜。结果:术后随访12~24mo。治疗组治愈率98%,复发率2%;对照组治愈率84%,复发率16%。两组复发率有统计学意义(χ2=4.62,P<0.05),两组均无明显并发症。结论:自体角膜缘干细胞移植术治疗复发性翼状胬肉疗效高,复发率低于带蒂结膜瓣转移术。

Abstract:

AIM:To investigate the efficiency of limbal conjunctival autografting technique in recurrent pterygium. METHODS: Forty-four eyes of 34 patients with recurrent pterygium were treated by limbal conjunctival autografting technique and 37 eyes of 32 patients with recurrent pterygium were treated by transplantation of conjunctival pedicle flap. Recurrence was defined as fibrovascular tissue crossing the corneoscleral limbus onto clear cornea in the area of previous pterygium excision. RESULTS: The follow-up periods ranged from 12 to 24 months. All 66 patients (81 eyes) were involved in the result analysis .In the therapeutic group, the cure rate was 98% and the recurrence rate was 2%, but in the control group the cure rate was 84% and the recurrence rate was 16%.There was a statistically significant difference in the recurrence rate between the patients who underwent limbal conjunctival autografting and those who underwent transplantation of conjunctival pedicle flap (χ2=4.62,P<0.05). In addition, no significant complications were noted. CONCLUSION: Limbal conjunctival autografting is an effective surgical technique for the treatment of recurrent pterygium. It has a low recurrence rate when compared with the transplantation of conjunctival pedicle flap technique.