AIM: To evaluate the clinical effect of transpupillary thermotherapy(TTT) in the treatment of retinal arterial macroaneurysms. METHODS: The clinical data of 24 patients 24 eyes with retinal arterial macroaneurysms treated with TTT were retrospectively analyzed. According to the size of neoplasia showed by fundus fluorescein angiography(FFA), diffenent laser spot (0.8-1.2mm) and power (22.4-36.8mJ) were selected. The visual acuity,neoplasia and tube wall instauration were observed. RESULTS: All the neoplasias were atrophied after TTT, and the wall instauration returned to normal. Central vision was increased in 17 eyes. CONCLUSION: TTT is an effective method to treat retinal arterial macroaneurysms, particularly to patients with bleeding and edema.