目的:探讨新鲜羊膜移植治疗难治性眼表疾病的疗效。方法:选择碱烧伤患者4例、角膜溃疡患者10例,共14例。采用单层羊膜移植,术后随访6～12mo。结果:14例术后临床上未见新鲜羊膜植片急性排斥反应;同时眼表迅速稳定。碱烧伤4例无角膜进行性溶解和穿孔,10例角膜溃疡患者中8例溃疡愈合,视力不同程度提高。结论:新鲜羊膜移植是重建眼表的有效方法,它可以减轻角膜的炎症反应,阻止角膜进行性溶解,加速眼表稳定,减少角膜新生血管的形成,为Ⅱ期角膜移植赢得宝贵时间,创造良好基础。

·AIM:To investigate the efficacy of fresh amniotic membrane transplantation in the treatment of refractory ocular surface diseases.·METHODS:Four cases of alkali burns and 10 cases of corneal ulcer in a total of 14 cases were selected.Single-layer amniotic membrane transplantion was performed,with postoperative follow-up of 6-12 months.·RESULTS:Fourteen cases had no sign of postoperative acute graft rejection clinically;At the same time,a rapid stabilization of ocular surface occurred.Alkali burn in 4 cases had non-progressive dissolution and perforation of cornea.In then 10 cases of corneal ulcers,8 cases had ulcer healing,visual acuity increased to varying degree.·CONCLUSION:Fresh amniotic membrane transplanta-tion for ocular surface reconstruction is an effective way,it can reduce corneal inflammation,prevent corneal progressive dissolution,accelerate ocular surface stability,reduce the formation of comeal neovascularization,gain precious time for the second period of corneal trans-plantation and create a sound foundation.·

R779.6